Disciples for Mac OS X is compatible with Intel Core Duo and PowerPC G4 or later systems with OS X versions 10.5 and later installed. Recommended minimum system: Intel Core Duo 2GHz processor and 1GB of RAM.

Disciples for Windows is compatible with Windows XP SP2 and later, as well as Vista 32-bit and x64 versions. Recommended minimum system: 2GHz processor and 1GB of RAM.